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Article

Thyrotropin-releasing hormone receptor (TRHR) gene is associated with essential hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2001

García S I, Porto P I, Dieuzeide G, Landa M S, Kirszner T, Plotquin Y, Gonzalez C, Pirola C J

Abstract excerpt

In essential hypertension, a polygenic and multifactorial syndrome, several genes interact with the environment to produce high blood pressure. Thyrotropin-releasing hormone (TRH) plays an important role in central cardiovascular regulation. We have described that TRH overexpression induces hypertension in a normal rat, which was reversed by TRH antisense treatment. This treatment also reduces the central TRH...

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PMID: 11566956
DOI: 10.1161/01.hyp.38.3.683

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TRHR
TRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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