Article
Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke.
Human genetics - 1 Jun 2006
Horan Martin, Newsway Vicky, Yasmin, Lewis Mark D, Easter Tammy E, Rees D Aled, Mahto Arti, Millar David S, Procter Annie M, Scanlon Maurice F, Wilkinson Ian B, Hall Ian P, Wheatley Amanda, Blakey John, Bath Philip M W, Cockcroft John R, Krawczak Michael, Cooper David N
Abstract excerpt
An increased prevalence of both hypertension and cerebrovascular stroke is apparent in growth hormone (GH) deficiency whilst hypertension is a frequent complication in acromegaly. This has suggested a possible link between GH, stature and arterial function. Since the risk of both hypertension and stroke also appears to be inversely correlated with adult height, we have instigated an exploratory study to assess...
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