Article
Association between a thyroid hormone receptor-α gene polymorphism and blood pressure but not with coronary heart disease risk.
American journal of hypertension - 1 Sept 2011
Goumidi Louisa, Gauthier Karine, Legry Vanessa, Mayi Thérèse Hèrvée, Houzet Alexia, Cottel Dominique, Montaye Michèle, Proust Carole, Kee Frank, Ferrières Jean, Arveiler Dominique, Ducimetière Pierre, Staels Bart, Dallongeville Jean, Chinetti Giulia, Flamant Frédéric, Amouyel Philippe, Meirhaeghe Aline
Abstract excerpt
BACKGROUND: Thyroid hormones (THs) exert multiple biological roles including effects on the cardiovascular system (lipid profile, blood pressure (BP) and cardiac output). The lipid-lowering actions of TH are mediated by the TH receptor-β whereas the mechanisms explaining the BP variations concomitant with the thyroid disorders are less understood. As the TH receptor-α (TR-α) has been associated with many of TH...
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