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Article

IRES-driven translation is stimulated separately by the FMDV 3'-NCR and poly(A) sequences

15 Oct 2002

Abstract excerpt

The 3' end region of foot-and-mouth disease virus (FMDV) consists of two distinct elements, a 90 nt untranslated region (3'-NCR) and a poly(A) tract. Removal of either the poly(A) tract or both the 3'-NCR and the poly(A) tract abrogated infectivity in susceptible cells in the context of a full-length cDNA clone. We have addressed the question of whether the impairment of RNA infectivity is related to defects at...

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PMID: 12384586
DOI: 10.1093/nar/gkf569

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