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Article

Chondrocyte apoptosis increases with age in the articular cartilage of adult animals

1 Apr 1998

Abstract excerpt

BACKGROUND: Apoptosis in vivo has been identified in developing cartilage from embryonic chick sterna and avian and murine growth plates. To date, no evidence exists that chondrocytes in articular cartilage undergo apoptosis. METHODS: We examined the distribution of cells demonstrating fragmented DNA in the articular knee cartilage of C57BL/6 mice (aged 11, 18, 24, and 30 months) and Wistar rats (aged 6, 12, and...

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PMID: 9566531
DOI: 10.1002/(sici)1097-0185(199804)250:4<418::aid-ar4>3.0.co;2-t

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