Article
A Combination of Amino Acid Mutations Leads to Resistance to Multiple Nucleoside Analogs in Reverse Transcriptases from HIV-1 Subtypes B and C.
Antimicrobial agents and chemotherapy - 18 Jan 2022
Boyer Paul L, Rehm Catherine A, Sneller Michael C, Mican JoAnn, Caplan Margaret R, Dewar Robin, Ferris Andrea L, Clark Patrick, Johnson Adam, Maldarelli Frank, Hughes Stephen H
Abstract excerpt
Resistance to anti-HIV drugs has been a problem from the beginning of antiviral drug treatments. The recent expansion of combination antiretroviral therapy worldwide has led to an increase in resistance to antiretrovirals; understanding the mechanisms of resistance is increasingly important. In this study, we analyzed reverse transcriptase (RT) variants based on sequences derived from an individual who had...
Topics
- Amino Acids
- Anti-HIV Agents
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Lamivudine
- Mutation
- Reverse Transcriptase Inhibitors
- Zidovudine