Article
Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2001
Herrmann S M, Funke-Kaiser H, Schmidt-Petersen K, Nicaud V, Gautier-Bertrand M, Evans A, Kee F, Arveiler D, Morrison C, Orzechowski H D, Elbaz A, Amarenco P, Cambien F, Paul M
Abstract excerpt
Cathepsin G (CTSG), a serine protease released from activated neutrophils, may cause platelet activation, leading to intravascular thrombosis, thus contributing to cardiovascular and cerebrovascular disease. Applying the candidate gene approach, we screened the 5'-flanking region and the entire coding region of the CTSG gene for genetic variation by using polymerase chain reaction/single-strand conformation...
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