Article
Tryptophan-dependent sensitized photoinactivation of colicin E1 channels in bilayer lipid membranes.
FEBS letters - 7 Sept 2001
Rokitskaya T I, Zakharov S D, Antonenko Y N, Kotova E A, Cramer W A
Abstract excerpt
The bacterial toxin colicin E1 is known to induce voltage-gated currents across a planar bilayer lipid membrane. In the present study, it is shown that the colicin-induced current decreased substantially upon illumination of the membrane in the presence of the photosensitizer, aluminum phthalocyanine. This effect was almost completely abolished by the singlet oxygen quencher, sodium azide. Using single tryptophan...
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