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Article

Split hand foot malformation is associated with a reduced level of Dactylin gene expression.

Clinical genetics - 1 Oct 2003

Basel D, DePaepe A, Kilpatrick M W, Tsipouras P

Abstract excerpt

Split hand foot malformation (SHFM) is a congenital limb malformation presenting with a median cleft of the hand and/or foot, syndactyly and polydactyly. SHFM is genetically heterogeneous with four loci mapped to date. Murine Dactylaplasia (Dac) is phenotypically similar, and it has been mapped to a syntenic region of 10q24, where SHFM3 has been localized. Structural alterations of the gene-encoding dactylin, a...

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PMID: 12974740
DOI: 10.1034/j.1399-0004.2003.00153.x

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Split hand foot malformation is associated with a reduced level of Dactylin gene expression.PMID 12974740Read ↗

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