Article
Evidence for joint genetic control of insulin sensitivity and systolic blood pressure in hispanic families with a hypertensive proband.
Circulation - 2 Jan 2001
Xiang A H, Azen S P, Raffel L J, Tan S, Cheng L S, Diaz J, Toscano E, Henderson P C, Hodis H N, Hsueh W A, Rotter J I, Buchanan T A
Abstract excerpt
BACKGROUND: The clustering of hypertension, insulin resistance, and obesity remains unexplained. We tested for genetic and nongenetic influences on the association among these traits in Hispanic families with hypertension. METHODS AND RESULTS: Blood pressure and body mass index (BMI) were measured in 331 members of 73 Hispanic families in which an index case (proband) had hypertension. Insulin sensitivity (S(I))...
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