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Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations

1 Jun 2001

Abstract excerpt

A live attenuated porcine reproductive and respiratory syndrome (PRRS) vaccine virus has been shown to revert to virulence under field conditions. In order to identify genetic virulence determinants, ORF1 from the attenuated vaccine virus and three Danish vaccine-derived field isolates was sequenced and compared with the parental strain of the vaccine virus (VR2332). This revealed five mutations that had occurred...

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PMID: 11369869
DOI: 10.1099/0022-1317-82-6-1263

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