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Article

Role of disease‐causing genes in sporadic pancreatic endocrine tumors: <i>MEN1</i> and<i>VHL</i>

8 Aug 2001

Abstract excerpt

Pancreatic endocrine tumors (PETs) occur in association with multiple endocrine neoplasia type 1 (MEN1) and von Hippel-Lindau (VHL) syndromes caused by germline alterations in MEN1 and VHL, respectively. It is thus expected that these genes will also be altered in a proportion of sporadic PETs. Indeed, MEN1 is altered in about 25% of nonfamilial PETs, although no mutations have been found in VHL. For all clinical...

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PMID: 11550286
DOI: 10.1002/gcc.1180

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