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Article

Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype.

Cancer - 1 Feb 2018

Keutgen Xavier M, Kumar Suresh, Gara Sudheer Kumar, Boufraqech Myriem, Agarwal Sunita, Hruban Ralph H, Nilubol Naris, Quezado Martha, Finney Richard, Cam Maggie, Kebebew Electron

Abstract excerpt

BACKGROUND: Nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) may be sporadic or inherited because of germline mutations associated with von Hippel-Lindau disease (VHL) or multiple endocrine neoplasia type 1 (MEN1). The clinical behavior of NFPanNETs is difficult to predict, even in tumors of the same stage and grade. The authors analyzed genotype-specific patterns of transcriptional messenger RNA...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Platelet-Derived Growth Factor beta

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Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 29149451
DOI: 10.1002/cncr.31057
PMCID: PMC5780230

Genes

MEN1
VHL
CDK4
CDK6
PDGFRB

Provenance

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