Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast.

The EMBO journal - 3 Sept 2001

Araki Y, Takahashi S, Kobayashi T, Kajiho H, Hoshino S, Katada T

Abstract excerpt

Two cytoplasmic mRNA-decay pathways have been characterized in yeast, and both are initiated by shortening of the 3'-poly(A) tail. In the major 5'-to-3' decay pathway, the deadenylation triggers removal of the 5'-cap, exposing the transcript body for 5'-to-3' degradation. An alternative 3'-to-5' decay pathway also follows the deadenylation and requires two multi-complexes: the exosome containing various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA, Fungal
Share to Adaptor Proteins, Signal Transducing
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Nuclear Proteins

Share to Recombinant Proteins

Share to Saccharomyces cerevisiae Proteins

Share to Secretory Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 11532933
DOI: 10.1093/emboj/20.17.4684
PMCID: PMC125587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast.PMID 11532933Read ↗

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex.Semantic proximity Read ↗

Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA.Semantic proximity Read ↗

Mutations in the G-domain of Ski7 cause specific dysfunction in non-stop decay.Semantic proximity Read ↗

SKI complex: A multifaceted cytoplasmic RNA exosome cofactor in mRNA metabolism with links to disease, developmental processes, and antiviral responsesSemantic proximity Read ↗

Poly(A) tail-dependent exonuclease AtRrp41p from Arabidopsis thaliana rescues 5.8 S rRNA processing and mRNA decay defects of the yeast ski6 mutant and is found in an exosome-sized complex in plant and yeast cells.Semantic proximity Read ↗

Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.Semantic proximity Read ↗

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.Semantic proximity Read ↗

Context-dependent dual role of SKI8 homologs in mRNA synthesis and turnover.Semantic proximity Read ↗

Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae.Semantic proximity Read ↗

The PolyA tail length of yeast histone mRNAs varies during the cell cycle and is influenced by Sen1p and Rrp6p.Semantic proximity Read ↗

The Saccharomyces cerevisiae small GTPase, Gsp1p/Ran, is involved in 3' processing of 7S-to-5.8S rRNA and in degradation of the excised 5'-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome.Semantic proximity Read ↗

Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.