Article
Contribution of HLA alleles in the regulation of antibody production in Lyme disease.
Frontiers in bioscience : a journal and virtual library - 1 Sept 2001
Wang P, Hilton E
Abstract excerpt
A small subset of patients infected with Borrelia burgdorferi (Bb) does not produce Bb specific antibody. Our research provides additional evidence of a genetic predisposition for seronegativity in some individuals with Lyme disease. Because human leukocyte antigen (HLA) class II, a heterodimeric glycoprotein, plays an essential role in the regulation of antibody production, we investigated the difference in HLA...
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