Identification of an essential cysteinyl residue in the ArsC arsenate reductase of plasmid R773.

doi:10.1021/bi00041a026

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Article

Identification of an essential cysteinyl residue in the ArsC arsenate reductase of plasmid R773.

Biochemistry - 17 Oct 1995

Liu J, Gladysheva T B, Lee L, Rosen B P

Abstract excerpt

The ArsC protein encoded by the arsenical resistance operon of plasmid R773 catalyzes the reduction of arsenate to arsenite in Escherichia coli. The reductase has been shown to require glutathione and glutaredoxin, suggesting that thiol chemistry might be involved in the reaction mechanism. The A...

Topics

Adenosine Triphosphatases
Arsenates
Arsenite Transporting ATPases
Arsenites
Cysteine
Drug Resistance, Microbial
Escherichia coli
Genes, Bacterial
Genotype
Ion Pumps
Kinetics
Multienzyme Complexes
Mutagenesis, Site-Directed
Operon
Oxidation-Reduction
Phenotype
R Factors
Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 7577935
DOI: 10.1021/bi00041a026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7577935-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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