Article
Circular minidefensins and posttranslational generation of molecular diversity.
Journal of leukocyte biology - 1 Sept 2001
Leonova L, Kokryakov V N, Aleshina G, Hong T, Nguyen T, Zhao C, Waring A J, Lehrer R I
Abstract excerpt
We purified two new minidefensins (RTD-2 and RTD-3) from the bone marrow of rhesus monkeys. Both were circular octadecapeptides that contained three intramolecular disulfide bonds and were homologous to RTD-1, a circular (theta) defensin previously described by Tang et al. (Science, 286, 498-502, 1999). However, whereas the 18 residues of RTD-1 represent spliced nonapeptide fragments derived from two different...
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