Article
The genetics of complex autoimmune diseases: non-MHC susceptibility genes.
Nature immunology - 1 Sept 2001
Wandstrat A, Wakeland E
Abstract excerpt
Susceptibility to complex autoimmune diseases (AIDs) is a multigenic phenotype affected by a variety of genetic and environmental or stochastic factors. After over a decade of linkage analyses, the identification of non-major histocompatibility complex (non-MHC) susceptibility alleles has proved to be difficult, predominantly because of extensive genetic heterogeneity and possible epistatic interactions among the...
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