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Article

Mutation detection in the alpha-1 antitrypsin gene (PI) using denaturing gradient gel electrophoresis.

Human mutation - 1 Sept 2001

Lodewyckx L, Vandevyver C, Vandervorst C, Van Steenbergen W, Raus J, Michiels L

Abstract excerpt

A method for mutation detection in the alpha-1 antitrypsin gene (protease inhibitor 1; PI) has been developed using denaturing gradient gel electrophoresis of PCR amplified gene fragments. Using this experimental approach, all common phenotypes and mutations could be detected. Denaturing gradient gel electrophoresis (DGGE) was compared with standard isoelectric focusing (IEF) in 20 potential alpha1-antitrypsin...

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PMID: 11524735
DOI: 10.1002/humu.1180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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