Article
Detection of the common alpha-1-antitrypsin variants by denaturing gradient gel electrophoresis.
Annals of human genetics - 1 Jul 1991
Johnson P H, Cadiou H, Hopkinson D A
Abstract excerpt
The well-characterized and highly polymorphic human alpha-1-antitrypsin (AAT) gene was used as a test locus to evaluate the general applicability of denaturing gradient gel electrophoresis (DGGE) for the detection of single base change polymorphisms. We report the resolution of all the major alleles, M1Ala, M1Val, M2, M3, S and Z and the identification of substantial genetic polymorphism in intron 3-4 by this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.