Article
A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments.
Bioinformatics (Oxford, England) - 10 Jul 2004
Dekker John P, Fodor Anthony, Aldrich Richard W, Yellen Gary
Abstract excerpt
MOTIVATION: The constituent amino acids of a protein work together to define its structure and to facilitate its function. Their interdependence should be apparent in the evolutionary record of each protein family: positions in the sequence of a protein family that are intimately associated in space or in function should co-vary in evolution. A recent approach by Ranganathan and colleagues proposes to look at...
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