Article
Sna41goa1, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polalpha.
Molecular genetics and genomics : MGG - 1 Aug 2001
Uchiyama M, Arai K, Masai H
Abstract excerpt
Proteins involved in the initiation of DNA replication play critical roles in the assembly and loading of replication complexes at replication origins. To gain further insight into the regulation of initiation, we screened in fission yeast for temperature-sensitive mutants which arrested at the G1/S boundary, and isolated nine mutants which arrested with a 1C DNA content at 36 degrees C. By linkage analysis, two...
Topics
- Carrier Proteins
- Cell Cycle
- DNA Polymerase I
- DNA Replication
- DNA, Fungal
- DNA-Binding Proteins
- Fungal Proteins
- G1 Phase
- Genetic Complementation Test
- Genetic Linkage
- Genotype