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Article

Significance of intron 6 sequence variations in the TP53 gene in Li-Fraumeni syndrome.

Cancer genetics and cytogenetics - 1 Aug 2001

Varley J M, McGown G, Thorncroft M, Kelsey A M, Birch J M

Abstract excerpt

Many polymorphisms have been reported in the TP53 gene. Some of these are within the coding region, and may affect the function of the p53 protein, others are within introns or non-coding regions, and their significance is unclear. Recently, a number of publications have claimed that polymorphisms within intron 6 are responsible for inherited predisposition to childhood malignancies, familial breast cancer, and...

Topics

Genes, p53
Genetic Predisposition to Disease
Humans
Introns
Li-Fraumeni Syndrome
Polymorphism, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 11520573
DOI: 10.1016/s0165-4608(01)00428-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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