Article
Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families.
Cancer research - 1 Aug 1997
Varley J M, McGown G, Thorncroft M, Santibanez-Koref M F, Kelsey A M, Tricker K J, Evans D G, Birch J M
Abstract excerpt
We have previously reported on the analysis of TP53 coding mutations in 12 classic Li-Fraumeni syndrome (LFS) families plus 9 families that were Li-Fraumeni-like (LFL) families (J. M. Birch et al., Cancer Res., 54: 1298-1304, 1994). Mutations were found in 6 of 12 LFS families and in 1 of 9 LFL f...
Topics
- Female
- Genes, p53
- Genetic Linkage
- Germ-Line Mutation
- Humans
- Li-Fraumeni Syndrome
- Male
- Mutation
- Promoter Regions, Genetic