Article
A prospective biological study in relation to a family with Li-Fraumeni syndrome.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 May 2012
Aurtenetxe Sáez Olaia, Calvo Begoña, Fernández-Teijeiro Ana, Pérez Pedro, Navajas Aurora
Abstract excerpt
INTRODUCTION: The Li-Fraumeni syndrome (LFS) is an autosomal dominant hereditary disorder associated with different tumor types in childhood and young adults. Approximately 70% of LFS cases contain germline mutations in the TP53 gene. We report a case of a family suspected of LFS. MATERIALS AND METHODS: The proband and four members of the family affected were diagnosed with cancer at an early age and they all...
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