Article
In vitro susceptibility of penicillin-resistant Streptococcus pneumoniae to levofloxacin, selection of resistant mutants, and time-kill synergy studies of levofloxacin combined with vancomycin, teicoplanin, fusidic acid, and rifampin.
Antimicrobial agents and chemotherapy - 1 Dec 1996
Klugman K P, Capper T, Bryskier A
Abstract excerpt
Among 180 clinical isolates of pneumococci, no strains were found to be resistant to levofloxacin (MIC, > or = 4 micrograms/ml) whereas 9% were resistant to ofloxacin and 7% were resistant to ciprofloxacin. Synergism was demonstrated by time-kill studies in nine of nine strains for the combinatio...
Topics
- Anti-Bacterial Agents
- Drug Synergism
- Drug Therapy, Combination
- Fusidic Acid
- Levofloxacin
- Mutation
- Ofloxacin
- Penicillin Resistance
- Rifampin
- Streptococcus pneumoniae
- Teicoplanin
- Vancomycin