Article
Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2001
Mahoney T S, Weyrich A S, Dixon D A, McIntyre T, Prescott S M, Zimmerman G A
Abstract excerpt
Engagement of adhesion molecules on monocytes and other myeloid leukocytes, which are effector cells of the innate immune system, not only tethers the leukocytes in place but also transmits outside-in signals that induce functional changes and alter gene expression. We found that a subset of mRNAs that are induced or amplified by adhesion of human monocytes to P-selectin via its surface ligand, P-selectin...
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