Article
The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor.
The Journal of biological chemistry - 7 Dec 2001
Klingler-Hoffmann M, Fodero-Tavoletti M T, Mishima K, Narita Y, Cavenee W K, Furnari F B, Huang H J, Tiganis T
Abstract excerpt
Glioblastoma multiforme (GBM) is the most aggressive type of glioma and GBMs frequently contain amplifications or mutations of the EGFR gene. The most common mutation results in a truncated receptor tyrosine kinase known as Delta EGFR that signals constitutively and promotes GBM growth. Here, we report that the 45-kDa variant of the protein tyrosine phosphatase TCPTP (TC45) can recognize Delta EGFR as a cellular...
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