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Article

Germ line insertion of mtDNA at the breakpoint junction of a reciprocal constitutional translocation.

Human genetics - 1 Aug 2001

Willett-Brozick J E, Savul S A, Richey L E, Baysal B E

Abstract excerpt

Constitutional chromosomal translocations are relatively common causes of human morbidity, yet the DNA double-strand break (DSB) repair mechanisms that generate them are incompletely understood. We cloned, sequenced and analyzed the breakpoint junctions of a familial constitutional reciprocal translocation t(9;11)(p24;q23). Within the 10-kb region flanking the breakpoints, chromosome 11 had 25% repeat elements,...

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Share to Chromosome Breakage
Share to Chromosome Segregation
Share to Chromosomes, Artificial, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

Share to Chromosomes, Human, Pair 9

Share to Gene Rearrangement

Share to Sequence Homology, Nucleic Acid

Share to Translocation, Genetic

Source

Identifiers

PMID: 11511928
DOI: 10.1007/s004390100564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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