Myosin-V is activated by binding secretory cargo and released in coordination with Rab/exocyst function.

Abstract excerpt

Cell organization requires motor-dependent transport of specific cargos along cytoskeletal elements. How the delivery cycle is coordinated with other events is poorly understood. Here we define the in vivo delivery cycle of myosin-V in its essential function of secretory vesicle transport along actin cables in yeast. We show that myosin-V is activated by binding a secretory vesicle and that myosin-V mutations...

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