Article
Role of CD47 in the induction of human naive T cell anergy.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2001
Avice M N, Rubio M, Sergerie M, Delespesse G, Sarfati M
Abstract excerpt
We recently reported that CD47 ligation inhibited IL-2 release by umbilical cord blood mononuclear cells activated in the presence of IL-12, but not IL-4, preventing the induction of IL-12Rbeta(2) expression and the acquisition of Th1, but not the Th2 phenotype. Here we show that in the absence of exogenous cytokine at priming, CD47 ligation of umbilical cord blood mononuclear cells promotes the development of...
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