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Article

Conformational properties of DNA fragments containing GAC trinucleotide repeats associated with skeletal displasias.

European biophysics journal : EBJ - 1 Jul 2001

Vorlícková M, Kejnovská I, Tumová M, Kypr J

Abstract excerpt

The human gene for cartilage oligomeric matrix protein contains five tandem repeats of the GAC trinucleotide. Its expansion by one repeat causes multiple epiphyseal dysplasia, while expansion by two repeats or, remarkably, deletion of one repeat causes pseudoachondroplasia. Here we used CD spectroscopy, PAGE and UV absorption spectroscopy to compare conformational properties of the DNA strands containing four,...

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PMID: 11508837
DOI: 10.1007/s002490000121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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