Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases.

Nucleic acids research - 15 Nov 2002

Hou Ming-Hon, Robinson Howard, Gao Yi-Gui, Wang Andrew H-J

Abstract excerpt

The potent anticancer drug actinomycin D (ActD) acts by binding to DNA GpC sequences, thereby interfering with essential biological processes including replication, transcription and topoisomerase. Certain neurological diseases are correlated with expansion of (CTG)n trinucleotide sequences, which contain many contiguous GpC sites separated by a single base pair. In order to characterize the binding of ActD to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Circular Dichroism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dactinomycin

Share to Macromolecular Substances

Share to Nervous System Diseases

Share to Nucleic Acid Denaturation

Share to Nucleic Acid Heteroduplexes

Share to Trinucleotide Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 12433994
DOI: 10.1093/nar/gkf619
PMCID: PMC137167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases.PMID 12433994Read ↗

The nature of actinomycin D binding to d(AACCAXYG) sequence motifs.Semantic proximity Read ↗

Molecular dynamics studies of trinucleotide repeat DNA involved in neurodegenerative disorders.Semantic proximity Read ↗

Structural Diversity of Triplet Repeat RNAsSemantic proximity Read ↗

Crystal structure of d(gcGXGAgc) with X=G: a mutation at X is possible to occur in a base-intercalated duplex for multiplex formation.Semantic proximity Read ↗

Length-dependent structure formation in Friedreich ataxia (GAA)n{middle dot}(TTC)n repeats at neutral pHSemantic proximity Read ↗

DM2 CCTG*CAGG repeats are crossover hotspots that are more prone to expansions than the DM1 CTG*CAG repeats in Escherichia coli.Semantic proximity Read ↗

Thermodynamic Stability of RNA Structures Formed by CNG Trinucleotide Repeats. Implication for Prediction of RNA StructureSemantic proximity Read ↗

Conformational properties of DNA fragments containing GAC trinucleotide repeats associated with skeletal displasias.Semantic proximity Read ↗

Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities.Semantic proximity Read ↗

An intramolecular quadruplex of (GGA)(4) triplet repeat DNA with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric interaction.Semantic proximity Read ↗

The base-intercalated duplexes of d(GCGAXAGC) with mutation at X (X=G, T or C).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.