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Article

Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases.

Nucleic acids research - 15 Nov 2002

Hou Ming-Hon, Robinson Howard, Gao Yi-Gui, Wang Andrew H-J

Abstract excerpt

The potent anticancer drug actinomycin D (ActD) acts by binding to DNA GpC sequences, thereby interfering with essential biological processes including replication, transcription and topoisomerase. Certain neurological diseases are correlated with expansion of (CTG)n trinucleotide sequences, whic...

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Identifiers

PMID: 12433994
DOI: 10.1093/nar/gkf619
PMCID: PMC137167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12433994-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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