Article
Ceruloplasmin enhances DNA damage induced by cysteine/iron in vitro.
Biochimie - 1 Jun 2001
Kim R H, Kwon O J, Park J W
Abstract excerpt
Ceruloplasmin (Cp) was found to promote the oxidative damage to DNA in vitro, as evidenced by the formation of 8-hydroxy-2'-deoxyguanosine and strand breaks, when incubated with a cysteine metal-catalyzed oxidation system (Cys-MCO) comprised of Fe(3+), O(2), and cysteine as an electron donor. The capacity of Cp to enhance oxidative damage to DNA was inhibited by hydroxyl radical scavengers such as sodium azide...
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