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Article

Influence of BCR/ABL fusion proteins on the course of Ph leukemias.

Acta biochimica Polonica - 1 Jan 2004

Telegeev Gennady D, Dubrovska Anna N, Dybkov Mykhaylo V, Maliuta Stanislav S

Abstract excerpt

The hallmark of chronic myeloid leukemia (CML) and a subset of acute lymphoblastic leukemia (ALL) is the presence of the Philadelphia chromosome as a result of the t(9;22) translocation. This gene rearrangement results in the production of a novel oncoprotein, BCR/ABL, a constitutively active tyrosine kinase. There is compelling evidence that the malignant transformation by BCR/ABL is critically dependent on its...

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PMID: 15448745

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BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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