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Article

Influence of BCR/ABL fusion proteins on the course of Ph leukemias.

Acta biochimica Polonica - 1 Jan 2004

Telegeev Gennady D, Dubrovska Anna N, Dybkov Mykhaylo V, Maliuta Stanislav S

Abstract excerpt

The hallmark of chronic myeloid leukemia (CML) and a subset of acute lymphoblastic leukemia (ALL) is the presence of the Philadelphia chromosome as a result of the t(9;22) translocation. This gene rearrangement results in the production of a novel oncoprotein, BCR/ABL, a constitutively active tyrosine kinase. There is compelling evidence that the malignant transformation by BCR/ABL is critically dependent on its...

Topics

Actins
Base Sequence
DNA, Neoplasm
Fusion Proteins, bcr-abl
Genes, abl
Humans
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Philadelphia Chromosome
Polymorphism, Single Nucleotide
Protein Structure, Tertiary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reverse Transcriptase Polymerase Chain Reaction

Sequence Deletion

U937 Cells

Source

Identifiers

PMID: 15448745

Genes

BCR

Provenance

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