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Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy.

Cancer gene therapy - 1 Jun 2001

Lee Y J, Galoforo S S, Battle P, Lee H, Corry P M, Jessup J M

Abstract excerpt

Tumor cells that express a fusion gene of Escherichia coli cytosine deaminase (CD) and herpes simplex virus type 1 thymidine kinase (TK) sequences activate and are subsequently killed by the nontoxic prodrugs 5-fluorocytosine and ganciclovir. We have previously developed a recombinant adenovirus containing the CD-TK fusion gene controlled by the human inducible heat shock protein 70 promoter so that heat at 41...

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Identifiers

PMID: 11498759
DOI: 10.1038/sj.cgt.7700310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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