Article
Enhancement of chemosensitivity in human bladder cancer cells by adenoviral-mediated p53 gene transfer.
Anticancer research - 1 Jan 2000
Miyake H, Hara I, Gohji K, Yamanaka K, Arakawa S, Kamidono S
Abstract excerpt
BACKGROUND: Drug resistance is a major problem in tumor chemotherapy, and recent studies have suggested that the differential sensitivity of cancer cells to chemotherapy is associated with different susceptibilities to undergoing apoptosis. The aim of this study was to evaluate the effects of introduction of wild-type p53 or p21WAF1/CIP1 (p21) on chemosensitivity of bladder cancer cells. MATERIALS AND METHODS:...
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