Article
Heterologous expression of the transcriptional regulator escargot inhibits megakaryocytic endomitosis.
The Journal of biological chemistry - 16 Nov 2001
Ballester A, Frampton J, Vilaboa N, Calés C
Abstract excerpt
Certain cell types escape the strict mechanisms imposed on the majority of somatic cells to ensure the faithful inheritance of parental DNA content. This is the case in many embryonic tissues and certain adult cells such as mammalian hepatocytes and megakaryocytes. Megakaryocytic endomitosis is characterized by repeated S phases followed by abortive mitoses, resulting in mononucleated polyploid cells. Several...
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