Article
Linkage disequilibrium pattern in the L-myc gene in Italian and Japanese non-small-cell lung-cancer patients.
International journal of cancer - 20 Sept 2001
Spinola M, Nomoto T, Manenti G, Falvella F S, Brega Massone P P, Conti B, Cataldo I, Valagussa P, Incarbone M, Miyamoto K, Ushijima T, Dragani T A
Abstract excerpt
Italian and Japanese non-small-cell lung-cancer patients were genotyped for an intragenic L-myc EcoRI restriction site polymorphism previously reported to be associated with lung-tumor prognosis in Asian populations but not in Caucasians. Screening of the L-myc sequence in Italian samples allowed identification of 2 additional 3'-UTR SNPs, located 2.3-3.0 kb from the EcoRI polymorphism, but no coding polymorphism...
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