Article
Tracking the common ancestry of antigenically distinct cancer variants.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2001
Schreiber K, Wu T H, Kast W M, Schreiber H
Abstract excerpt
In the months and years after first diagnosis, cancers often show an increase in their malignancy such as faster growth, resistance to chemo- and/or hormonal therapy, and loss of antigens targeted by immunotherapy. Our objective was to develop a model in which one can track the changes occurring as a result of in vivo immune selection, such as the loss of antigen, the emergence of previously hidden antigens, or...
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