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Article

Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice.

Human molecular genetics - 1 Aug 2001

Haider N B, Naggert J K, Nishina P M

Abstract excerpt

The rd7 mouse is a model for hereditary retinal degeneration characterized clinically by retinal spotting throughout the fundus and late onset retinal degeneration, and histologically by retinal dysplasia manifesting as folds and whorls in the photoreceptor layer. This study demonstrates that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11487564
DOI: 10.1093/hmg/10.16.1619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11487564-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Related research

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Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice.PMID 11487564Read ↗

Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors.Semantic proximity Read ↗

Overexpression of retinal degeneration slow (RDS) protein adversely affects rods in the rd7 model of enhanced S-cone syndrome.Semantic proximity Read ↗

Nuclear Receptor Subfamily 2 Group E Member 3 (NR2E3): Role in Retinal Development and DiseaseSemantic proximity Read ↗

A Hybrid Photoreceptor Expressing Both Rod and Cone Genes in a Mouse Model of Enhanced S-Cone SyndromeSemantic proximity Read ↗

Mapping of genetic modifiers of Nr2e3 rd7/rd7 that suppress retinal degeneration and restore blue cone cells to normal quantity.Semantic proximity Read ↗

Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseasesSemantic proximity Read ↗

The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration.Semantic proximity Read ↗

<i>Nr2e3</i> functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates Retinitis Pigmentosa and Enhanced S-cone Syndrome modelsSemantic proximity Read ↗

Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.Semantic proximity Read ↗

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal developmentSemantic proximity Read ↗

Loss of NR2E3 disrupts rod photoreceptor cell maturation causing a fate switch late in human retinal developmentSemantic proximity Read ↗

Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate.Semantic proximity Read ↗

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