Article
The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002
Milam Ann H, Rose Linda, Cideciyan Artur V, Barakat Mark R, Tang Wai-Xing, Gupta Nisha, Aleman Tomas S, Wright Alan F, Stone Edwin M, Sheffield Val C, Jacobson Samuel G
Abstract excerpt
Normal human retinal development involves orderly generation of rods and cones by complex mechanisms. Cell-fate specification involves progenitor cell lineage and external signals such as soluble factors and cell-cell interactions. In most inherited human retinal degenerations, including retinitis pigmentosa, a mutant gene causes loss of visual function, death of mature rods, and eventually death of all cone...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.