Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping of genetic modifiers of Nr2e3 rd7/rd7 that suppress retinal degeneration and restore blue cone cells to normal quantity.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2008

Haider Neena B, Zhang Weidong, Hurd Ron, Ikeda Akihiro, Nystuen Arne M, Naggert Jürgen K, Nishina Patsy M

Abstract excerpt

The retinal degeneration 7 (rd7) mouse, lacking expression of the Nr2e3 gene, exhibits retinal dysplasia and a slow, progressive degeneration due to an abnormal production of blue opsin-expressing cone cells. In this study we evaluated three strains of mice to identify alleles that would slow or ameliorate the retinal degeneration observed in Nr2e3 (rd7/rd7) mice. Our studies reveal that genetic background...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Retinal Cone Photoreceptor Cells
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Orphan Nuclear Receptors

Share to Receptors, Cytoplasmic and Nuclear

Share to Retinal Degeneration

Share to Species Specificity

Source

Identifiers

PMID: 18286335
DOI: 10.1007/s00335-008-9092-2

Genes

CAST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping of genetic modifiers of Nr2e3 rd7/rd7 that suppress retinal degeneration and restore blue cone cells to normal quantity.PMID 18286335Read ↗

Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice.Semantic proximity Read ↗

Overexpression of retinal degeneration slow (RDS) protein adversely affects rods in the rd7 model of enhanced S-cone syndrome.Semantic proximity Read ↗

Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors.Semantic proximity Read ↗

A Hybrid Photoreceptor Expressing Both Rod and Cone Genes in a Mouse Model of Enhanced S-Cone SyndromeSemantic proximity Read ↗

Nuclear Receptor Subfamily 2 Group E Member 3 (NR2E3): Role in Retinal Development and DiseaseSemantic proximity Read ↗

Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.Semantic proximity Read ↗

Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseasesSemantic proximity Read ↗

<i>Nr2e3</i> functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates Retinitis Pigmentosa and Enhanced S-cone Syndrome modelsSemantic proximity Read ↗

Genetic variations strongly influence phenotypic outcome in the mouse retina.Semantic proximity Read ↗

Dhdds T206A and Dhdds K42E knock-in mouse models of retinitis pigmentosa 59 are phenotypically similar.Semantic proximity Read ↗

A novel mutation in Prph2, a gene regulated by Nr2e3, causes retinal degeneration and outer-segment defects similar to Nr2e3 ( rd7/rd7 ) retinas.Semantic proximity Read ↗

Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.