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Article

Involvement of oxidative stress in Alzheimer disease.

Journal of neuropathology and experimental neurology - 1 Jul 2006

Nunomura Akihiko, Castellani Rudy J, Zhu Xiongwei, Moreira Paula I, Perry George, Smith Mark A

Abstract excerpt

Genetic and lifestyle-related risk factors for Alzheimer disease (AD) are associated with an increase in oxidative stress, suggesting that oxidative stress is involved at an early stage of the pathologic cascade. Moreover, oxidative stress is mechanistically and chronologically associated with other key features of AD, namely, metabolic, mitochondrial, metal, and cell-cycle abnormalities. Contrary to the commonly...

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Identifiers

PMID: 16825950
DOI: 10.1097/01.jnen.0000228136.58062.bf

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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