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Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis

1 Sept 2001

Abstract excerpt

We show that the Mre11 complex associates with E2F family members via the Nbs1 N terminus. This association and Nbs1 phosphorylation are correlated with S-phase checkpoint proficiency, whereas neither is sufficient individually for checkpoint activation. The Nbs1 E2F interaction occurred near the Epstein-Barr virus origin of replication as well as near a chromosomal replication origin in the c-myc promoter region...

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Identifiers

PMID: 11486038
DOI: 10.1128/mcb.21.17.6006-6016.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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