Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology.

Journal of radiation research - 1 Apr 2018

Miyamoto Tatsuo, Akutsu Silvia Natsuko, Tauchi Hiroshi, Kudo Yoshiki, Tashiro Satoshi, Yamamoto Takashi, Matsuura Shinya

Abstract excerpt

DNA double-strand breaks (DSBs) induced by ionizing radiation (IR) are the initial and critical step in major alteration of genetic information and cell death. To prevent deleterious effects, DNA repair systems recognize and re-join DNA DSBs in human cells. It has been suggested that there are individual differences in radiosensitivity within human populations, and that variations in DNA repair genes might...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to ATM gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Editing

Share to Genetic Predisposition to Disease

Share to Genetics, Population

Share to Mutation

Share to Radiation Tolerance

Source

Open in PubMed Open full text

Identifiers

PMID: 29528422
DOI: 10.1093/jrr/rry007
PMCID: PMC5941146

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology.PMID 29528422Read ↗

Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells.Semantic proximity Read ↗

Genetic variation in radiation-induced cell death.Semantic proximity Read ↗

Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.Semantic proximity Read ↗

Genetic susceptibility to radiation.Semantic proximity Read ↗

New approaches to assessing the effects of mutagenic agents on the integrity of the human genome.Semantic proximity Read ↗

Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk.Semantic proximity Read ↗

Cancer predisposition, radiosensitivity and the risk of radiation-induced cancers. I. Background.Semantic proximity Read ↗

Genotype-phenotype relationships in ataxia-telangiectasia and variants.Semantic proximity Read ↗

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.Semantic proximity Read ↗

Heterogeneity in ataxia-telangiectasia: classical phenotype associated with intermediate cellular radiosensitivity.Semantic proximity Read ↗

Radiosensitivity of human fibroblasts is associated with amino acid substitution variants in susceptible genes and correlates with the number of risk alleles.Semantic proximity Read ↗

Gene expression phenotype in heterozygous carriers of ataxia telangiectasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.