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Article

Selection of HCV NS5A quasispecies during IFN therapy in patients with chronic HCV.

Digestive diseases and sciences - 1 Jul 2001

Paterson M, Laxton C, Goldin R D, Ackrill A M, Foster G R

Abstract excerpt

Interferon treatment of chronic hepatitis C virus infection is successful in a minority of patients. The sequence of the interferon sensitivity determining region (ISDR) of the NS5A protein may determine the outcome of therapy in patients infected with HCV genotype 1. To determine whether IFN treatment caused selection of ISDR quasispecies and whether sequences bearing the putative IFN-resistance motif (HCV-J...

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Identifiers

PMID: 11478490
DOI: 10.1023/a:1010623417345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Selection of HCV NS5A quasispecies during IFN therapy in patients with chronic HCV.PMID 11478490Read ↗

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Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.Semantic proximity Read ↗

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.Semantic proximity Read ↗

Analysis of HCV quasispecies dynamic under selective pressure of combined therapy.Semantic proximity Read ↗

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