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Article

Salt-Independent Abnormality of Antimicrobial Activity in Cystic Fibrosis Airway Surface Fluid

1 Jul 2001

Abstract excerpt

The link between the genetic defect in cystic fibrosis (CF) and the recently described breach in pulmonary host defense has focused on the role of salt and water metabolism in the airways. Using a human bronchial xenograft model we demonstrate a salt-independent abnormality in bacterial killing in CF airway surface fluid (ASF). Biochemical characterization implicates the absence or dysfunction of a molecule...

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Identifiers

PMID: 11472971
DOI: 10.1165/ajrcmb.25.1.4436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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