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Article

[Beta-catenin mutations in a common skin cancer: pilomatricoma].

Bulletin du cancer - 1 Sept 1999

Durand M, Molès J P

Abstract excerpt

The normal hair development requires WNT signalling pathways. A constitutive activation of beta-catenin, one of the components of this cascade, induces an abnormal proliferation of hair matrix cells. This activation is observed in a human skin tumours called pilomatricoma. Mutations of the beta-catenin gene are detected in 75% of the tumours analysed.

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PMID: 10519964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Beta-catenin mutations in a common skin cancer: pilomatricoma].PMID 10519964Read ↗

beta-Catenin mutation and its nuclear localization are confirmed to be frequent causes of Wnt signaling pathway activation in pilomatricomasSemantic proximity Read ↗

Pilomatricomas contain activating mutations in beta-catenin.Semantic proximity Read ↗

beta-Catenin gene mutation in human hair follicle-related tumors.Semantic proximity Read ↗

A common human skin tumour is caused by activating mutations in beta-catenin.Semantic proximity Read ↗

Comparison of Benign and Malignant Pilomatricomas Using Whole-exome Sequencing.Semantic proximity Read ↗

beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair folliclesSemantic proximity Read ↗

Low frequency of beta-catenin gene mutations in pilomatricoma.Semantic proximity Read ↗

Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA ‐1 expressionSemantic proximity Read ↗

The association between multiple pilomatrixomas and APC gene mutations.Semantic proximity Read ↗

Mutation analysis of multiple pilomatricomas in a patient with myotonic dystrophy type 1 suggests a DM1-associated hypermutation phenotypeSemantic proximity Read ↗

Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin.Semantic proximity Read ↗

Mutation analysis of multiple pilomatricomas in a patient with myotonic dystrophy type 1 suggests a DM1-associated hypermutation phenotype.Semantic proximity Read ↗

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