Article
Analysis of a polycytosine tract and heteroplasmic length variation in the mitochondrial DNA D-loop of patients with diabetes, MELAS syndrome and race-matched controls.
Diabetic medicine : a journal of the British Diabetic Association - 1 May 2001
Gill-Randall R, Sherratt E J, Thomas A W, Gagg J W, Lee A, Alcolado J C
Abstract excerpt
AIM: The T to C substitution at position 16189 nt of the human mitochondrial genome has been associated with the development of heteroplasmic length variation in the control region of mtDNA. Previous reports have suggested that this defect may be associated with the development of other pathogenic mtDNA mutations, including the diabetogenic A to G mutation in the tRNALEU(UUR). Recently the 16189 nt variant has...
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